Ru 486 breast cancer

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Not a MyNAP member yet?Previously, we demonstrated that the progestin components nortestosterone derivatives in oral contraceptives are able to stimulate human breast cancer cell proliferation via an estrogen receptor ER -mediated mechanism.By Phyllida Brown.Study record managers: refer to the Data Element Definitions if submitting registration or results information.Breast cancer is the most frequently diagnosed malignant neoplasia and is a leading cause of cancer death in females worldwide.To evaluate agonist or antagonist activities of the progestin analog RUwe have assayed proteins that are specifically induced by progestin in the progesterone receptor positive human breast cancer cell lines MCF7 and T47D.

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New research shows that RU - that's the abortion drug - might be helpful in controlling breast cancer.

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PIP: Considerable animal research and clinical trials demonstrate that progesterone antagonists could treat hormone-dependent breast cancers.The study, published on Thursday in the journal Science, suggests a potential new path to protect women genetically predisposed to these cancers by using drugs to interfere with a hormone called progesterone, the researchers said.The progestin and glucocorticoid antagonist RU was tested on the growth of severalcell lines in culture.

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